One-page view of all members
Principal InvestigatorPhilipps-Universität MarburgDepartment of Pharmacy, Vice-Director “Chemikum-Marburg” e.V.Phone: +49-6421 28-25843workEmail: wegscheid-gerlach@staff.uni-marburg.deINTERNETLink: Project Ö (Wegscheid/Dehnen)Link: BiographyExpertise
Pharmaceutical chemistry, computer aided molecular design, molecular modelling, pharmaceutical and chemical education
University Education
2006 | Doctoral degree in Pharmaceutical Chemistry (Dr. rer. nat.), Philipps-Universität Marburg, “Privileged structures for the inhibition of serine proteases – docking and directed design in the protein binding pocket”, thesis advisor: Prof. Dr. Gerhard Klebe |
2002 | State licensed pharmacist |
1997-2001 | Studies of Pharmacy, Philipps-Universität Marburg |
Professional Experience
since 2013 | Permanent position as “Akademischer Rat” |
2010-2013 | Permanent position as scientific staff scientist |
2007-2009 | Lab Head computational chemistry, Bayer Health Care, Berlin |
2006-2007 | Postdoc computational chemistry, Lilly Pharma, Hamburg |
2003-2006 | Stipend of the DFG-research training group “Protein function at the atomic level” |
2002 | Practical training for pharmacists, Apotheke am Brommygrün, Wilhelmshaven |
2001-2002 | Practical training for pharmacists, Hoffmann La-Roche, Basel |
Honours, Awards and other Proofs of Qualification
2016-2017 | Co-Organisation of the Studium Generale on Emil von Behring (12 Lectures) |
since 2014 | Member of the academic senate at Philipps-Universität Marburg |
since 2011 | Deputy executive director Chemikum Marburg e.V. |
since 2011 | Member of the examination board “Industriemeister Pharmazie” of the Kassel-Marburg Chamber of Industry and Commerce |
2012-2013 | Co-Organisation of the Studium Generale on Drug Devlopment and the conflicts thereof (12 Lectures) |
2009 | Co-Editior for the special issue “The Medicinal Chemistry of Protease Inhibitors” Journal Current Topics in Medicinal Chemistry |
2007-2008 | Associated member of the EU FP7 Marie Curie Research Training Network “Chromatin Plasticity” |
Selected Publications
- H. Steuber, M. Zentgraf, C. Gerlach, C. A. Sotriffer, A. Heine, G. Klebe
Expect the unexpected or caveat for drug designers: multiple structure determinations using aldose reductase crystals treated under varying soaking and co-crystallisation conditions
J. Mol. Biol. 363 (1), 174 (2006). - C. Gerlach, M. Smolinski, H. Steuber, C. A. Sotriffer, A. Heine, D. G. Hangauer, G. Klebe
Thermodynamic inhibition profile of a cyclopentyl and a cyclohexyl derivative towards thrombin: the same but for different reasons
Angew. Chem. Int. Ed. 46 (44), 8511 (2007). - C. Gerlach, M. Münzel, B. Baum, H. D. Gerber, T. Craan, W. E. Diederich, G. Klebe
KNOBLE: a knowledge-based approach for the design and synthesis of readily accessible small-molecule chemical probes to test protein binding
Angew. Chem. Int. Ed. 46 (47), 9105 (2007). - C. Gerlach, H. Broughton, A. Zaliani
FTree query construction for virtual screening: a statistical analysis
J. Comput. Aided Mol. Des. 22 (2), 111 (2008). - J. Degen, C. Wegscheid-Gerlach, A. Zaliani, M. Rarey
On the art of compiling and using “drug-like” chemical fragment spaces
Chem. Med. Chem. 3 (10), 1503 (2008). - B. Baum, M. Mohamed, M. Zayed, C. Gerlach, A. Heine, D. Hangauer, G. Klebe
More than a simple lipophilic contact: a detailed thermodynamic analysis of nonbasic residues in the S1 pocket of thrombin
J. Mol. Biol. 390 (1), 56 (2009). - T. Brandt, N. Holzmann, L. Muley, M. Khayat, C. Wegscheid-Gerlach, B. Baum, A. Heine, D. Hangauer, G. Klebe
Congeneric but still distinct: how closely related trypsinligands exhibit different thermodynamic and structural properties
J. Mol. Biol. 405 (5), 1170 (2011). - S. Oppermann, F. C. Schrader, K. Elsässer, A. M. Dolga, A. L. Kraus, N. Doti, C. Wegscheid-Gerlach, M. Schlitzer, C. Culmsee
Novel N-phenyl-substituted thiazolidinediones protect neural cells against glutamate- and tBid-induced toxicity
J. Pharmacol. Exp. Ther. 350 (2), 273 (2014). - M. T. Barho, S. Oppermann, F. C. Schrader, I. Degenhardt, K. Elsässer, C. Wegscheid-Gerlach, C. Culmsee, M. Schlitzer
N-acyl-derivatives of 4-pheoxyaniline as neuroprotective agents
Chem. Med. Chem. 9 (10), 2260 (2014).
Patents
- M. Koppitz, V.Schulze, D. Kosemund, H. Schirok, B. Bader, P. Lienau, T. Marquardt,
C. Wegscheid-Gerlach, G. Siemeister, S. Prechtl, A. M.Wengner, U. Bömer, Triazolopyridin-Derivate (EP 2507236 B1 (2010)). - J. Hübner, C. Wegscheid-Gerlach, O. Panknin, S. Ring, S. Bäurle, C. Huwe, K. Nowak, R. Nubbemeyer, H.-P. Muhn, Pyridinone derivatives and pharmaceutical compositions thereof (WO 2011076687 A1 (2009)).
- M. Koppitz, B. Bader, U. Bömer, B. Kreft, P. Lienau, T. Marquardt, S. Prechtl,
G. Siemeister, C. Wegscheid-Gerlach, Substituted imidazoquinoxalines (US 8729082 B2 (2009)). - B. Bader, U. Bömer, S. Ince, M. Koppitz, P. Lienau, T. Marquardt, D. Nguyen, S. Prechtl, G. Siemeister, C. Wegscheid-Gerlach, Substituted aminoquinoxalines as tyrosine threonine kinase inhibitors (US 20120263708 A1 (2009)).