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Photo of Dr. Christof WEGSCHEID-GERLACH
Principal InvestigatorPhilipps-Universität MarburgDepartment of Pharmacy, Vice-Director “Chemikum-Marburg” e.V.Phone: +49-6421 28-25843Link: Project Ö (Wegscheid/Dehnen)Link: Biography


Pharmaceutical chemistry, computer aided molecular design, molecular modelling, pharmaceutical and chemical education

University Education

2006Doctoral degree in Pharmaceutical Chemistry (Dr. rer. nat.), Philipps-Universität Marburg, “Privileged structures for the inhibition of serine proteases – docking and directed design in the protein binding pocket”, thesis advisor: Prof. Dr. Gerhard Klebe
2002State licensed pharmacist
1997-2001Studies of Pharmacy, Philipps-Universität Marburg

Professional Experience

since 2013Permanent position as “Akademischer Rat”
2010-2013Permanent position as scientific staff scientist
2007-2009Lab Head computational chemistry, Bayer Health Care, Berlin
2006-2007Postdoc computational chemistry, Lilly Pharma, Hamburg
2003-2006Stipend of the DFG-research training group “Protein function at the atomic level”
2002Practical training for pharmacists, Apotheke am Brommygrün, Wilhelmshaven
2001-2002Practical training for pharmacists, Hoffmann La-Roche, Basel

Honours, Awards and other Proofs of Qualification

2016-2017Co-Organisation of the Studium Generale on Emil von Behring (12 Lectures)
since 2014Member of the academic senate at Philipps-Universität Marburg
since 2011Deputy executive director Chemikum Marburg e.V.
since 2011Member of the examination board “Industriemeister Pharmazie” of the Kassel-Marburg Chamber of Industry and Commerce
2012-2013Co-Organisation of the Studium Generale on Drug Devlopment and the conflicts thereof (12 Lectures)
2009Co-Editior for the special issue “The Medicinal Chemistry of Protease Inhibitors” Journal Current Topics in Medicinal Chemistry
2007-2008Associated member of the EU FP7 Marie Curie Research Training Network “Chromatin Plasticity”

Selected Publications

  1. H. Steuber, M. Zentgraf, C. Gerlach, C. A. Sotriffer, A. Heine, G. Klebe
    Expect the unexpected or caveat for drug designers: multiple structure determinations using aldose reductase crystals treated under varying soaking and co-crystallisation conditions
    J. Mol. Biol. 363 (1), 174 (2006).
  2. C. Gerlach, M. Smolinski, H. Steuber, C. A. Sotriffer, A. Heine, D. G. Hangauer, G. Klebe
    Thermodynamic inhibition profile of a cyclopentyl and a cyclohexyl derivative towards thrombin: the same but for different reasons
    Angew. Chem. Int. Ed. 46 (44), 8511 (2007).
  3. C. Gerlach, M. Münzel, B. Baum, H. D. Gerber, T. Craan, W. E. Diederich, G. Klebe
    KNOBLE: a knowledge-based approach for the design and synthesis of readily accessible small-molecule chemical probes to test protein binding
    Angew. Chem. Int. Ed. 46 (47), 9105 (2007).
  4. C. Gerlach, H. Broughton, A. Zaliani
    FTree query construction for virtual screening: a statistical analysis
    J. Comput. Aided Mol. Des. 22 (2), 111 (2008).
  5. J. Degen, C. Wegscheid-Gerlach, A. Zaliani, M. Rarey
    On the art of compiling and using “drug-like” chemical fragment spaces
    Chem. Med. Chem. 3 (10), 1503 (2008).
  6. B. Baum, M. Mohamed, M. Zayed, C. Gerlach, A. Heine, D. Hangauer, G. Klebe
    More than a simple lipophilic contact: a detailed thermodynamic analysis of nonbasic residues in the S1 pocket of thrombin
    J. Mol. Biol. 390 (1), 56 (2009).
  7. T. Brandt, N. Holzmann, L. Muley, M. Khayat, C. Wegscheid-Gerlach, B. Baum, A. Heine, D. Hangauer, G. Klebe
    Congeneric but still distinct: how closely related trypsinligands exhibit different thermodynamic and structural properties
    J. Mol. Biol. 405 (5), 1170 (2011).
  8. S. Oppermann, F. C. Schrader, K. Elsässer, A. M. Dolga, A. L. Kraus, N. Doti, C. Wegscheid-Gerlach, M. Schlitzer, C. Culmsee
    Novel N-phenyl-substituted thiazolidinediones protect neural cells against glutamate- and tBid-induced toxicity
    J. Pharmacol. Exp. Ther. 350 (2), 273 (2014).
  9. M. T. Barho, S. Oppermann, F. C. Schrader, I. Degenhardt, K. Elsässer, C. Wegscheid-Gerlach, C. Culmsee, M. Schlitzer
    N-acyl-derivatives of 4-pheoxyaniline as neuroprotective agents
    Chem. Med. Chem. 9 (10), 2260 (2014).


  1. M. Koppitz, V.Schulze, D. Kosemund, H. Schirok, B. Bader, P. Lienau, T. Marquardt,
    C. Wegscheid-Gerlach, G. Siemeister, S. Prechtl, A. M.Wengner, U. Bömer, Triazolopyridin-Derivate (EP 2507236 B1 (2010)).
  2. J. Hübner, C. Wegscheid-Gerlach, O. Panknin, S. Ring, S. Bäurle, C. Huwe, K. Nowak, R. Nubbemeyer, H.-P. Muhn, Pyridinone derivatives and pharmaceutical compositions thereof (WO 2011076687 A1 (2009)).
  3. M. Koppitz, B. Bader, U. Bömer, B. Kreft, P. Lienau, T. Marquardt, S. Prechtl,
    G. Siemeister, C. Wegscheid-Gerlach, Substituted imidazoquinoxalines (US 8729082 B2 (2009)).
  4. B. Bader, U. Bömer, S. Ince, M. Koppitz, P. Lienau, T. Marquardt, D. Nguyen, S. Prechtl, G. Siemeister, C. Wegscheid-Gerlach, Substituted aminoquinoxalines as tyrosine threonine kinase inhibitors (US 20120263708 A1 (2009)).